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CGP 78608 hydrochloride
CAS No. 1135278-54-4
CGP 78608 hydrochloride( —— )
Catalog No. M32842 CAS No. 1135278-54-4
CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 187 | In Stock |
|
| 10MG | 231 | In Stock |
|
| 25MG | 508 | In Stock |
|
| 50MG | 719 | In Stock |
|
| 100MG | 1004 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCGP 78608 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity.
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DescriptionCGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity.
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In VitroCGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites.CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity.
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In VivoCGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR | NMDAR
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Research Area——
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Indication——
Chemical Information
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CAS Number1135278-54-4
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Formula Weight414.58
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Molecular FormulaC11H14BrClN3O5P
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Purity>98% (HPLC)
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Solubility——
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SMILESC(N[C@@H](P(=O)(O)O)C)C1=C2C(NC(=O)C(=O)N2)=CC(Br)=C1.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21.?
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