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AZD-1979
CAS No. 1254035-84-1
AZD-1979( AZD1979 | AZD 1979 )
Catalog No. M11025 CAS No. 1254035-84-1
A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAZD-1979
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM.
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DescriptionA potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM; shows no apparent affinity for MCHR2 (Ki>40 uM); dose-dependently reduces body weight in DIO mice leading to improved homeostasis model assessment-index of insulin sensitivity.Obesity Phase 1 Clinical.
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In Vitro——
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In VivoIn DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs.
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SynonymsAZD1979 | AZD 1979
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PathwayGPCR/G Protein
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TargetMCHR
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RecptorMCHR
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Research AreaMetabolic Disease
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IndicationObesity
Chemical Information
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CAS Number1254035-84-1
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Formula Weight462.506
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Molecular FormulaC25H26N4O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (72.06 mM)
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SMILESO=C(N1CC(OC2=CC=C(CN(C3)CC43COC4)C=C2)C1)C5=NN=C(C6=CC=C(OC)C=C6)O5
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Chemical Name(3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johansson A, et al. J Med Chem. 2016 Mar 24;59(6):2497-511.
2. Ploj K, et al. Br J Pharmacol. 2016 Sep;173(18):2739-51.
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