ST-4206( ST 4206 | ST4206 )

Catalog No. M10995 CAS No. 1246018-36-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ST-4206
Note

Research use only, not for human use.
Brief Description

A metabolite of ST1535, which is potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.
Description

A metabolite of ST1535, which is potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.
In Vitro

ST4206 inhibits agonist-induced cAMP accumulation with an IC50 of 990 nM.
In Vivo

ST4206 (10, 20, and 40 mg/kg, p.o.) antagonizes haloperidol-induced catalepsy, and increases motor activity in a dose dependent manner in mice.ST4206 (20 and 40 mg/kg) significantly increases the number of contralateral turns induced by l-DOPA in rats. ST4206 is orally active at concentrations of 10, 20, and 40 mg/kg in haloperidol-induced catalepsy in mice.
Synonyms

ST 4206 | ST4206
Pathway

Apoptosis
Target

Adenosine Receptor
Recptor

Adenosine Receptor
Research Area

——
Indication

——

CAS Number

1246018-36-9
Formula Weight

286.299
Molecular Formula

C12H14N8O
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(CCC1=NC(N)=C2N=C(N3N=CC=N3)N(C)C2=N1)=O
Chemical Name

4-(6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)butan-2-one

1. Stasi MA, et al. Eur J Pharmacol. 2015 Aug 15;761:353-61.

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