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PF-05150122
CAS No. 1235406-03-7
PF-05150122( PF05150122 )
Catalog No. M10944 CAS No. 1235406-03-7
PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 369 | In Stock |
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| 5MG | 287 | In Stock |
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| 10MG | 430 | In Stock |
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| 25MG | 710 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-05150122
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NoteResearch use only, not for human use.
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Brief DescriptionPF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM.
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DescriptionPF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.Pain Phase 1 Discontinued.
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In VitroPF-05186462 inhibits human Nav1.7 channels (IC50=21 nM) in HEK293 cells.PF-05186462 exhibits a high plasma protein binding rate.
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In Vivo——
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SynonymsPF05150122
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorSodium Channel
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1235406-03-7
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Formula Weight531.885
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Molecular FormulaC19H10ClF4N5O3S2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-chloro-2-fluoro-4-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042.
2. Jones HM, et al. Clin Pharmacokinet. 2016 Jul;55(7):875-87.
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