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Epetraborole hydrochloride

CAS No. 1234563-16-6

Epetraborole hydrochloride( GSK2251052 hydrochloride | AN3365 )

Catalog No. M10938 CAS No. 1234563-16-6

Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 258 In Stock
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Biological Information

  • Product Name
    Epetraborole hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS).
  • Description
    Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates; MIC90s against 302 Bacteroides fragilis and Bacteroides thetaiotaomicron strains are 4 and 8 μg/ml, respectively; a single amino acid polymorphism (P329) within the editing domain of LeuRS reduces susceptibility to GSK2251052.Bacterial Infection Phase 2 Discontinued
  • In Vitro
    Epetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes. Cell Viability Assay Cell Line:Anaerobes isolates Concentration:0-32 μg/mL Incubation Time:Result:Showed MIC50/MIC90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively.
  • In Vivo
    ——
  • Synonyms
    GSK2251052 hydrochloride | AN3365
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    bacterialleucyltRNAsynthetase
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    1234563-16-6
  • Formula Weight
    273.521
  • Molecular Formula
    C11H17BClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 28 mg/mL
  • SMILES
    B1(C2=C(C=CC=C2OCCCO)C(O1)CN)O.Cl
  • Chemical Name
    1-Propanol, 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Goldstein EJ, et al. Antimicrob Agents Chemother. 2013 May;57(5):2401-4. 2. Tenero D, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3334-9. 3. O'Dwyer K, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. 4. Gupta A, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3219-21.
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