RV1088( RV-1088 | RV 1088 )

Catalog No. M10903 CAS No. 1229606-73-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RV1088
Note

Research use only, not for human use.
Brief Description

RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually.
Description

RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM; also reduces IL-6 production effectively with IC50 of 1.66 nM, RV1088 is significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira; TNF-α, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50s.
In Vitro

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In Vivo

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Synonyms

RV-1088 | RV 1088
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

p38 MAPK
Research Area

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Indication

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CAS Number

1229606-73-8
Formula Weight

578.673
Molecular Formula

C33H34N6O4
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide

1. To WS, et al. Br J Pharmacol. 2015 Aug;172(15):3805-16.

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