RV1088

Research use only, not for human use.

RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually.

RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM; also reduces IL-6 production effectively with IC50 of 1.66 nM, RV1088 is significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira; TNF-α, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50s.

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RV-1088 | RV 1088

MAPK/ERK Signaling

p38 MAPK

p38 MAPK

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1229606-73-8

578.673

C33H34N6O4

>98% (HPLC)

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N-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide

(-20℃)

With Ice Pack

≥ 2 years