PF-04756956( PF04756956 | PF 04756956 )

Catalog No. M10894 CAS No. 1228934-52-8

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Datasheet

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HPLC

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Product Name

PF-04756956
Note

Research use only, not for human use.
Brief Description

A potent, selective CCK1 receptor agonist with EC50 of 0.47 nM; elicits no biological response at the CCK2 receptors.
Description

A potent, selective CCK1 receptor agonist with EC50 of 0.47 nM; elicits no biological response at the CCK2 receptors; demonstrates robust weight loss in a diet-induced obese rat model with very low systemic exposure.
In Vitro

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In Vivo

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Synonyms

PF04756956 | PF 04756956
Pathway

GPCR/G Protein
Target

Cholecystokinin Receptor
Recptor

Cholecystokinin Receptor
Research Area

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Indication

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CAS Number

1228934-52-8
Formula Weight

649.799
Molecular Formula

C40H39N7O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(4S)-4-((1H-indazol-3-yl)methyl)-6-(2-((R)-2-(3,5-dimethylbenzyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-5(6H)-one

1. Desai AJ, et al. J Med Chem. 2015 Dec 24;58(24):9562-77. 2. Cameron KO, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2943-7.

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