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Alosetron hydrochloride
CAS No. 122852-69-1
Alosetron hydrochloride( GR-68755X | GR-68755 )
Catalog No. M10889 CAS No. 122852-69-1
A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 29 | In Stock |
|
| 25MG | 67 | In Stock |
|
| 50MG | 107 | In Stock |
|
| 100MG | 173 | In Stock |
|
| 200MG | 257 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAlosetron hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.
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DescriptionA potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.Irritable Bowel Syndrome Approved(In Vivo):Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis.
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In Vitro——
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In VivoDexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis.
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SynonymsGR-68755X | GR-68755
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT3
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Research AreaOther Indications
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IndicationIrritable Bowel Syndrome
Chemical Information
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CAS Number122852-69-1
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Formula Weight330.812
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Molecular FormulaC17H19ClN4O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCl.CN1C2=C(C3=CC=CC=C13)C(=O)N(CC1=C(C)NC=N1)CC2
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Chemical Name1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Audolfsson G, et al. Aliment Pharmacol Ther. 1999 May;13 Suppl 2:39-47.
2. Zhai J, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):374-82.
3. Saslow SB, et al. Gut. 1998 May;42(5):628-34.
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