Alosetron hydrochloride

CAS No. 122852-69-1

Alosetron hydrochloride( GR-68755X | GR-68755 )

Catalog No. M10889 CAS No. 122852-69-1

A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 29 In Stock
25MG 67 In Stock
50MG 107 In Stock
100MG 173 In Stock
200MG 257 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Alosetron hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.
  • Description
    A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.Irritable Bowel Syndrome Approved(In Vivo):Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis.
  • In Vitro
    ——
  • In Vivo
    Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis.
  • Synonyms
    GR-68755X | GR-68755
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT3
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    122852-69-1
  • Formula Weight
    330.812
  • Molecular Formula
    C17H19ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    Cl.CN1C2=C(C3=CC=CC=C13)C(=O)N(CC1=C(C)NC=N1)CC2
  • Chemical Name
    1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Audolfsson G, et al. Aliment Pharmacol Ther. 1999 May;13 Suppl 2:39-47. 2. Zhai J, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):374-82. 3. Saslow SB, et al. Gut. 1998 May;42(5):628-34.
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