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Alosetron

CAS No. 122852-42-0

Alosetron( GR-68755X | GR-68755 )

Catalog No. M10888 CAS No. 122852-42-0

A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Alosetron
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.
  • Description
    A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.Irritable Bowel Syndrome Approved.
  • In Vitro
    ——
  • In Vivo
    Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis.
  • Synonyms
    GR-68755X | GR-68755
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    122852-42-0
  • Formula Weight
    294.351
  • Molecular Formula
    C17H18N4O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    Cc1c([nH]cn1)CN2CCc3c(c4ccccc4n3C)C2=O
  • Chemical Name
    1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Audolfsson G, et al. Aliment Pharmacol Ther. 1999 May;13 Suppl 2:39-47. 2. Zhai J, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):374-82. 3. Saslow SB, et al. Gut. 1998 May;42(5):628-34.
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