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BTK-IN-23
CAS No. 1227206-13-4
BTK-IN-23( —— )
Catalog No. M10877 CAS No. 1227206-13-4
BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBTK-IN-23
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NoteResearch use only, not for human use.
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Brief DescriptionBTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM.
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DescriptionBTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM; displays 5-fold and 77-fold selectivity over BMX and TEC, >300-fold selectivity over FGR, SRC and MELK; demonstrates potent inhibition of anti-IgE stimulated CD63 expression on basophils, with an EC50 of 257 nM; shows improved stability compared to GDC-0834.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetBTK
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RecptorBTK
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Research Area——
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Indication——
Chemical Information
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CAS Number1227206-13-4
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Formula Weight529.594
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Molecular FormulaC27H24FN7O2S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(6-fluoro-2-methyl-3-(5-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)benzo[b]thiophene-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Young WB, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):575-9.
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