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Amelparib
CAS No. 1227156-72-0
Amelparib( JPI-289 | JPI289 )
Catalog No. M10874 CAS No. 1227156-72-0
Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
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| 50MG | 2322 | Get Quote |
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| 100MG | 3060 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAmelparib
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NoteResearch use only, not for human use.
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Brief DescriptionAmelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
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DescriptionAmelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.Stroke Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsJPI-289 | JPI289
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP
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Research AreaNeurological Disease
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IndicationStroke
Chemical Information
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CAS Number1227156-72-0
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Formula Weight343.427
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Molecular FormulaC19H25N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (291.19 mM)
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SMILESO=C1C2=C(NCCC2)C3=C(OCC)C=C(CN4CCOCC4)C=C3N1
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Chemical Name10-ethoxy-8-[(morpholin-4-yl)methyl]-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679.
2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6.
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