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A-1048400

CAS No. 1219624-62-0

A-1048400( A1048400 )

Catalog No. M10826 CAS No. 1219624-62-0

A novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    A-1048400
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
  • Description
    A novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively; shows no significant activity against L-type Ca2+ channels (IC50=28 uM); reverses tactile allodynia in model of capsaicin-induced secondary hypersensitivity (EC50=300-365 ng/ml), without effect on hemodynamic function; blocks native N- and T-type Ca2+ currents in rat dorsal root ganglion neurons (IC50=3.0 and 1.6 uM), attenuates nociceptive, neuropathic and inflammatory pain in vivo.Pain Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    A1048400
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1219624-62-0
  • Formula Weight
    543.711
  • Molecular Formula
    C36H37N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1N(CC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)CCCC1(C5=CC=CC=C5)C6=CC=CC=C6
  • Chemical Name
    1-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Scott VE, et al. Biochem Pharmacol. 2012 Feb 1;83(3):406-18.
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