Pidotimod

Research use only, not for human use.

Pidotimod is an immunostimulant.

Pidotimod is an immunostimulant.(In Vivo):In toxicology study in animals, Pidotimod (oral gavage; 800 mg/kg;12 months) is non-toxic in rats and is non-toxic dogs at 600 mg/kg. Pidotimod is non-teratogenic in rats (600 mg/kg orally or 1000 mg/kg IV) and has no effects on subsequent embryofoetal development in rats (up to 1000 mg/kg/day),it has no perinatal or postnatal toxic effects in rats (600 mg/kg orally).In ex vivo experiments in mice, Pidotimod (intraperitoneal administration; 200 mg/kg; 5 days) potentiats natural killer (NK) cell activity and produces an increase in the proliferative response to mitogens such as concanavalin A (ConA) and interleukin-2 (IL-2).Pidotimod (intraperitoneal administration; 10-100 mg/kg) normalizes depletion of peritoneal macrophage numbers, and significantly increases macrophage superoxide anion (O2–) production in methylprednisolone-induced immunosuppressed mice.

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In toxicology study in animals, Pidotimod (oral gavage; 800 mg/kg;12 months) is non-toxic in rats and is non-toxic dogs at 600 mg/kg. Pidotimod is non-teratogenic in rats (600 mg/kg orally or 1000 mg/kg IV) and has no effects on subsequent embryofoetal development in rats (up to 1000 mg/kg/day),it has no perinatal or postnatal toxic effects in rats (600 mg/kg orally).In ex vivo experiments in mice, Pidotimod (intraperitoneal administration; 200 mg/kg; 5 days) potentiats natural killer (NK) cell activity and produces an increase in the proliferative response to mitogens such as concanavalin A (ConA) and interleukin-2 (IL-2). Pidotimod (intraperitoneal administration; 10-100 mg/kg) normalizes depletion of peritoneal macrophage numbers, and significantly increases macrophage superoxide anion (O2–) production in methylprednisolone-induced immunosuppressed mice.

PGT/1A

Others

Other Targets

Others

Inflammation/Immunology

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121808-62-6

244.27

C9H12N2O4S

>98% (HPLC)

Water: 10 mg/mL (40.93 mM); DMSO: 49 mg/mL (200.59 mM)

O=C([C@H]1N(C([C@H](CC2)NC2=O)=O)CSC1)O

(R)-3-((S)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years