Chalcone 4 hydrate( —— )

Catalog No. M10740 CAS No. 1202866-96-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Chalcone 4 hydrate
Note

Research use only, not for human use.
Brief Description

Chalcone 4 hydrate is a potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM.
Description

Chalcone 4 hydrate is a potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM; shows no activities for CCL5 and CXCL8 chemokines; inhibits calcium responses mediated by CXCR4 and prevents CXCR4 internalization; blocks chemotaxis of human peripheral blood lymphocytes ex vivo, shows activity in vivo in mouse model of allergic eosinophilic airway inflammation.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

——

CAS Number

1202866-96-3
Formula Weight

306.74
Molecular Formula

C16H15ClO4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC=C(Cl)C=C1)/C=C/C2=CC=C(O)C(OC)=C2.O.[F,Cl,Br,I]
Chemical Name

(E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate

1. Gasparik V, et al. ACS Med Chem Lett. 2011 Dec 9;3(1):10-4. 2. Hachet-Haas M, et al. J Biol Chem. 2008 Aug 22;283(34):23189-99.

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