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GW405833 hydrochloride
CAS No. 1202865-22-2
GW405833 hydrochloride( GW-405833 | GW 405833 )
Catalog No. M10739 CAS No. 1202865-22-2
A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGW405833 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
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DescriptionA potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1; causes a concentration-dependent inhibition of forskolin-mediated cAMP accumulation in CHO-K1 cells with EC50 of 0.65 nM, elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain.
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In Vitro——
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In Vivo——
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SynonymsGW-405833 | GW 405833
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1202865-22-2
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Formula Weight483.814
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Molecular FormulaC23H25Cl3N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (258.36 mM)
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SMILES——
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Chemical Name(2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Valenzano KJ, et al. Neuropharmacology. 2005 Apr;48(5):658-72.
2. Whiteside GT, et al. Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72.
3. Hu B, et al. Pain. 2009 Jun;143(3):206-12.
4. Li AL, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):296-305.
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