Cart
sales@molnova.com
GW405833 hydrochloride
CAS No. 1202865-22-2
GW405833 hydrochloride( GW-405833 | GW 405833 )
Catalog No. M10739 CAS No. 1202865-22-2
A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGW405833 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
-
DescriptionA potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1; causes a concentration-dependent inhibition of forskolin-mediated cAMP accumulation in CHO-K1 cells with EC50 of 0.65 nM, elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain.
-
In Vitro——
-
In Vivo——
-
SynonymsGW-405833 | GW 405833
-
PathwayGPCR/G Protein
-
TargetCannabinoid Receptor
-
RecptorCannabinoid Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1202865-22-2
-
Formula Weight483.814
-
Molecular FormulaC23H25Cl3N2O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (258.36 mM)
-
SMILES——
-
Chemical Name(2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Valenzano KJ, et al. Neuropharmacology. 2005 Apr;48(5):658-72.
2. Whiteside GT, et al. Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72.
3. Hu B, et al. Pain. 2009 Jun;143(3):206-12.
4. Li AL, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):296-305.
molnova catalog
related products
-
CB2R/FAAH?modulator-...
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting CB2R and FAAH, acting as a CB2R agonist (Ki = 10.8 nM) and FAAH inhibitor (IC50 = 6.2 μM), with a Ki value of 152.9 nM for CB1R.
-
PSB-SB-487
PSB-SB-487 is antagonist of GPR55.
-
Tetrahydrocannabivar...
Tetrahydrocannabivarin is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, this effect profile suggests therapeutic activity in obesity, perhaps with a lowered risk of depressive side effects. Tetrahydrocannabivarin exhibits anticonvulsant effects in a piriform cortical brain slice model of epileptiform activity.
