UR-144( UR 144 | UR144 )

Catalog No. M10716 CAS No. 1199943-44-6

COA

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HNMR

HPLC

MSDS

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Product Name

UR-144
Note

Research use only, not for human use.
Brief Description

A potent, selective full agonist of the peripheral cannabinoid receptor CB2 with Ki of 1.8 nM.
Description

A potent, selective full agonist of the peripheral cannabinoid receptor CB2 with Ki of 1.8 nM, >80-fold selectivity over CB2 (Ki=150 nM); possesses an EC50 of 421 nM for human CB1 receptors, and 72 nM for human CB2 receptors, produces bradycardia and hypothermia in rats at a dose of 10 mg/kg.
In Vitro

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In Vivo

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Synonyms

UR 144 | UR144
Pathway

GPCR/G Protein
Target

Cannabinoid Receptor
Recptor

Cannabinoid Receptor
Research Area

Neurological Disease
Indication

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CAS Number

1199943-44-6
Formula Weight

311.461
Molecular Formula

C21H29NO
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCCCn1cc(c2c1cccc2)C(=O)C3C(C3(C)C)(C)C
Chemical Name

(1-Pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

1. Banister SD, et al. ACS Chem Neurosci. 2015 Aug 19;6(8):1445-58. 2. Dhopeshwarkar A, et al. J Pharmacol Exp Ther. 2016 Aug;358(2):342-51.

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