Sinogliatin( Dorzagliatin | HMS-5552 | RO-5305552 )

Catalog No. M10662 CAS No. 1191996-10-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Sinogliatin
Note

Research use only, not for human use.
Brief Description

Sinogliatin (Dorzagliatin, HMS-5552, RO-5305552) is a novel, first-in-class glucokinase activator (GKS) to treat diabetes mellitus.
Description

Sinogliatin (Dorzagliatin, HMS-5552, RO-5305552) is a novel, first-in-class glucokinase activator (GKS) to treat diabetes mellitus.Diabetes Phase 3 Clinical.
In Vitro

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In Vivo

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Synonyms

Dorzagliatin | HMS-5552 | RO-5305552
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Glucokinase
Recptor

Glucokinase
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1191996-10-7
Formula Weight

462.93
Molecular Formula

C22H27ClN4O5
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C)C[C@H](N1CC(OC2=CC=CC=C2Cl)=CC1=O)C(NC3=NN(C[C@H](O)CO)C=C3)=O
Chemical Name

(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide

1. Song L, et al. Clin Pharmacokinet. 2018 Oct;57(10):1307-1323.

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