Home - Products - Cytoskeleton/Cell Adhesion Molecules - Glucokinase - ML266

ML266

CAS No. 1462267-08-8

ML266( —— )

Catalog No. M37610 CAS No. 1462267-08-8

ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 μM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	117	In Stock
2MG	65	In Stock
5MG	107	In Stock
10MG	169	In Stock
25MG	344	In Stock
50MG	463	In Stock
100MG	674	In Stock
200MG	Get Quote	In Stock
500MG	1414	In Stock
1G	Get Quote	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

ML266
Note

Research use only, not for human use.
Brief Description

ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 μM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function.
Description

ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 μM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Glucokinase
Recptor

Glucokinase
Research Area

——
Indication

——

Chemical Information

CAS Number

1462267-08-8
Formula Weight

496.35
Molecular Formula

C24H22BrN3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (251.84 mM; Ultrasonic )
SMILES

CN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(Br)cc1)c1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].?

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

related products

Palmitelaidic Acid

Palmitelaidic Acid is one of the most abundant fatty acids in serum and tissue.
Jujuboside A

Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the treatment of Alzheimer?s disease.
4'-Demethylpodophyll...

4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.

Sign In Join Free