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ML266
CAS No. 1462267-08-8
ML266( —— )
Catalog No. M37610 CAS No. 1462267-08-8
ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 μM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 73 | Get Quote |
|
| 5MG | 107 | Get Quote |
|
| 10MG | 169 | Get Quote |
|
| 25MG | 333 | Get Quote |
|
| 50MG | 458 | Get Quote |
|
| 100MG | 653 | Get Quote |
|
| 500MG | 1368 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameML266
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NoteResearch use only, not for human use.
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Brief DescriptionML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 μM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function.
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DescriptionML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 μM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetGlucokinase
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RecptorGlucokinase
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Research Area——
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Indication——
Chemical Information
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CAS Number1462267-08-8
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Formula Weight496.35
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Molecular FormulaC24H22BrN3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (251.84 mM; Ultrasonic )
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SMILESCN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(Br)cc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].?
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