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ML266

CAS No. 1462267-08-8

ML266( —— )

Catalog No. M37610 CAS No. 1462267-08-8

ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 μM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	73	Get Quote
5MG	107	Get Quote
10MG	169	Get Quote
25MG	333	Get Quote
50MG	458	Get Quote
100MG	653	Get Quote
500MG	1368	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

ML266
Note

Research use only, not for human use.
Brief Description

ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 μM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function.
Description

ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 μM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Glucokinase
Recptor

Glucokinase
Research Area

——
Indication

——

Chemical Information

CAS Number

1462267-08-8
Formula Weight

496.35
Molecular Formula

C24H22BrN3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (251.84 mM; Ultrasonic )
SMILES

CN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(Br)cc1)c1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].?

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