Calpeptin( Calpeptin | Benzylcarbonyl-leu-nleu-H | N-Cbz-leu-nleu-al. )

Catalog No. M10597 CAS No. 117591-20-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Calpeptin
Note

Research use only, not for human use.
Brief Description

Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.
Description

Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.
In Vitro

——
In Vivo

Animal Model:C57BL/6 female mice (Eight-week-old).Dosage:0.04 mg/mouse.Administration:Intraperitoneally three times weekly for 28 days (together with Bleo).Result:Inhibited the collagen deposition and increase of calpain activity in the NSC-125066 treated mouse lung tissues.
Synonyms

Calpeptin | Benzylcarbonyl-leu-nleu-H | N-Cbz-leu-nleu-al.
Pathway

Proteasome/Ubiquitin
Target

Cysteine Protease
Recptor

Calpain 1(human platelets)| Calpain 1(porcine erythrocytes)| Calpain 2(porcine kidney)| Papainb
Research Area

Cancer
Indication

——

CAS Number

117591-20-5
Formula Weight

362.46
Molecular Formula

C20H30N2O4
Purity

>98% (HPLC)
Solubility

DMSO:72 mg/mL (198.64 mM); Ethanol:72 mg/mL (198.64 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CCCC)=O)CC(C)C
Chemical Name

benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxohexan-2-yl)amino)pentan-2-yl)carbamate

1. Tsujinaka T, et al. Biochem Biophys Res Commun. 1988, 153(3), 1201-1208.

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