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YM543
CAS No. 1174340-24-9
YM543( YM-543 | YM 543 )
Catalog No. M10592 CAS No. 1174340-24-9
A potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameYM543
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1.
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DescriptionA potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1; dose-dependently and significantly reduces blood glucose levels and improves glucose tolerance with a concomitant increase in urinary glucose excretion, also significantly reduces hyperglycemia in type 2 diabetic mice.Diabetes Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsYM-543 | YM 543
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PathwayGPCR/G Protein
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TargetSGLT
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RecptorSGLT
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number1174340-24-9
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Formula Weight500.611
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Molecular FormulaC28H38NO7+
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(2S,3R,4R,5S,6R)-2-(5-(azulen-2-ylmethyl)-2-hydroxyphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, 2-hydroxy-N,N,N-trimethylethan-1-aminium salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yokono M, et al. Endocr Res. 2013 Feb 1.
2. Ikegai K, et al. Bioorg Med Chem. 2013 Jul 1;21(13):3934-48.
3. Nakada N. Pharm Res. 2017 Apr;34(4):874-886.
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