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AMG 747
CAS No. 1000690-85-6
AMG 747( AMG747 | AMG-747 )
Catalog No. M10008 CAS No. 1000690-85-6
A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAMG 747
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NoteResearch use only, not for human use.
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Brief DescriptionA nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.
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DescriptionA nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia; dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats and humans.Schizophrenia Phase 2 Discontinued
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In Vitro——
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In VivoTilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats.
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SynonymsAMG747 | AMG-747
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PathwayMembrane Transporter/Ion Channel
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TargetGlyT
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RecptorGlyT
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number1000690-85-6
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Formula Weight378.395
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Molecular FormulaC20H21F3N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)CN1CCN([C@H](C2=CC=CC=C2)C3=CC=CC(C(F)(F)F)=C3)CC1
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Chemical Name1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dunayevich E, et al. Schizophr Res. 2017 Apr;182:90-97.
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