PI3Kγ inhibitor 1( —— )

Catalog No. M10575 CAS No. 1172118-03-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PI3Kγ inhibitor 1
Note

Research use only, not for human use.
Brief Description

A potent PI3Kγ inhibitor.
Description

A potent PI3Kγ inhibitor.
In Vitro

In Table 3, PI3Kγ inhibitor 1 (Compound 168) inhibits PI3Kδ, PI3Kγ, PI3Kα and PI3Kβ with IC50s of <100 nM, <100 nM, <10 μM and <10 μM, respectively. PI3Kγ inhibitor 1 inhibits B cell proliferation with an EC50<100 nM.
In Vivo

——
Synonyms

——
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Cancer
Indication

——

CAS Number

1172118-03-4
Formula Weight

586.6663
Molecular Formula

C32H26N8O2S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=C2C(=CC=C1)C=C(N(C2=O)C3=CC=CC=C3C)CN4C5=NC=NC(=C5C(=N4)C6=CC7=C(C=C6)N=C(S7)NC(=O)C)N
Chemical Name

Acetamide, N-[6-[4-amino-1-[[1,2-dihydro-8-methyl-2-(2-methylphenyl)-1-oxo-3-isoquinolinyl]methyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-benzothiazolyl]-

1. Patent WO 2014004470.

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