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A-967079
CAS No. 1170613-55-4
A-967079( A967079 | A 967079 )
Catalog No. M10572 CAS No. 1170613-55-4
A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 56 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 143 | In Stock |
|
| 50MG | 245 | In Stock |
|
| 100MG | 419 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA-967079
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.
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DescriptionA potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively; displays >1,000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors; exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED50=23.2 mg/kg), attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals; orally bioavailable.Pain Preclinical
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In Vitro——
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In Vivo——
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SynonymsA967079 | A 967079
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRP/TRPV Channel
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1170613-55-4
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Formula Weight207.24
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Molecular FormulaC12H14FNO
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Purity>98% (HPLC)
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SolubilityDMS : 100 mg/mL482.53 mM;H2O : < 0.1 mg/mL
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SMILESCCC(/C(C)=C/C1=CC=C(F)C=C1)=N\O
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Chemical Name(1E,3E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-one oxime
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen J, et al. Pain. 2011 May;152(5):1165-72.
2. McGaraughty S, et al. Mol Pain. 2010 Mar 5;6:14.
3. Trevisan G, et al. Brain. 2016 May;139(Pt 5):1361-77.
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