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Home - Products - Wnt/Notch/Hedgehog - Wnt/beta/catenin - KY02111

KY02111

CAS No. 1118807-13-8

KY02111( KY02111 | KY 02111 | KY-02111 )

Catalog No. M10427 CAS No. 1118807-13-8

KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
10MG 33 In Stock
25MG 73 In Stock
50MG 133 In Stock
100MG 200 In Stock
200MG 296 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    KY02111
  • Note
    Research use only, not for human use.
  • Brief Description
    KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling.
  • Description
    KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
  • In Vitro
    KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs.KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4.KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner.KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin.
  • In Vivo
    ——
  • Synonyms
    KY02111 | KY 02111 | KY-02111
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Wnt/beta/catenin
  • Recptor
    Wnt
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1118807-13-8
  • Formula Weight
    376.86
  • Molecular Formula
    C18H17ClN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 75 mg/mL (199.01 mM)
  • SMILES
    O=C(NC1=NC2=CC=C(Cl)C=C2S1)CCC3=CC=C(OC)C(OC)=C3
  • Chemical Name
    N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liu F, et al. J Pharmacol Exp Ther, 2008, 327(3), 827-839.
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