CPTH6

Research use only, not for human use.

CPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor.

CPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor; CPTH6 exerts a significant inhibitory effect on HAT activity of both pCAF and Gcn5, whereas it does not affect p300 and CBP HAT activity; decrease acetylation of histone H3 specifically at lysine 18 in a dose-dependent fashion, does not affect H3 histone methylation at lysines 9 and 4; induces cell-cycle perturbation and apoptosis in AML cells, induces differentiation in AML and neuroblastoma cells; impairs autophagy and reduces autophagosome turnover through an impairment of their degradation pathway.

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Chromatin/Epigenetic

HAT

HAT

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1099614-81-9

305.824

C15H16ClN3S

>98% (HPLC)

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CC1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)Cl)C1

Cyclopentanone, 3-methyl-, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone

(-20℃)

With Ice Pack

≥ 2 years