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CPTH6

CAS No. 1099614-81-9

CPTH6( —— )

Catalog No. M10380 CAS No. 1099614-81-9

CPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CPTH6
  • Note
    Research use only, not for human use.
  • Brief Description
    CPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor.
  • Description
    CPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor; CPTH6 exerts a significant inhibitory effect on HAT activity of both pCAF and Gcn5, whereas it does not affect p300 and CBP HAT activity; decrease acetylation of histone H3 specifically at lysine 18 in a dose-dependent fashion, does not affect H3 histone methylation at lysines 9 and 4; induces cell-cycle perturbation and apoptosis in AML cells, induces differentiation in AML and neuroblastoma cells; impairs autophagy and reduces autophagosome turnover through an impairment of their degradation pathway.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    HAT
  • Recptor
    HAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1099614-81-9
  • Formula Weight
    305.824
  • Molecular Formula
    C15H16ClN3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)Cl)C1
  • Chemical Name
    Cyclopentanone, 3-methyl-, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Trisciuoglio D, et al. Clin Cancer Res. 2012 Jan 15;18(2):475-86. 2. Ragazzoni Y, et al. Cell Death Dis. 2013 Mar 7;4:e524. 3. Di Martile M, et al. Oncotarget. 2016 Mar 8;7(10):11332-48. 4. Chimenti F, et al. J Med Chem. 2009 Jan 22;52(2):530-6.
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