Cart
sales@molnova.com
AZD-7624
CAS No. 1095004-78-6
AZD-7624( AZD7624 )
Catalog No. M10370 CAS No. 1095004-78-6
AZD-7624 is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
|
| 5MG | 155 | In Stock |
|
| 10MG | 250 | In Stock |
|
| 25MG | 455 | In Stock |
|
| 50MG | 668 | In Stock |
|
| 100MG | 995 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAZD-7624
-
NoteResearch use only, not for human use.
-
Brief DescriptionAZD-7624 is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0.
-
DescriptionAZD-7624 is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0, displays 15-fold selectivity for p38α over p38β MAPK and >10,000-fold selectivity over p38γ and p38δ MAPK; inhibits LPS-induced TNF-α and IL-6 release in human alveolar macrophages pIC50 of 9.2 and 8.8, respectively; shows potential for prevention of exacerbations in COPD.COPD Phase 2 Discontinued.
-
In VitroAZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50s of 8.4, 8.1, and 9.0.
-
In Vivo——
-
SynonymsAZD7624
-
PathwayMAPK/ERK Signaling
-
Targetp38 MAPK
-
Recptorp38 MAPK
-
Research AreaInflammation/Immunology
-
IndicationCOPD
Chemical Information
-
CAS Number1095004-78-6
-
Formula Weight491.56
-
Molecular FormulaC27H30FN5O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 62.5 mg/mL (127.15 mM)
-
SMILESO=C(NC1CC1)C2=CC(N3C(C(NC4(C5=CC=CC=C5OCCNC)CC4)=NC=C3)=O)=C(C)C(F)=C2
-
Chemical NameN-cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Patel NR, et al. Int J Chron Obstruct Pulmon Dis. 2018 Mar 27;13:1009-1019.
2. Pehrson R, et al. Pharmacol Exp Ther. 2018 Mar 16. pii: jpet.117.246132.
molnova catalog
related products
-
BI-2865
BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively.
-
LY2228820 dimesylate
LY2228820 dimesylate (Ralimetinib) is a potent, selective, orally available inhibitor p38 MAPK with IC50 of 5.3 and 3.2 nM for p38α and p38β, respectively.
-
Gossypetin
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.
