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AZD-7624
CAS No. 1095004-78-6
AZD-7624( AZD7624 )
Catalog No. M10370 CAS No. 1095004-78-6
AZD-7624 is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 455 | In Stock |
|
| 50MG | 668 | In Stock |
|
| 100MG | 995 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD-7624
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NoteResearch use only, not for human use.
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Brief DescriptionAZD-7624 is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0.
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DescriptionAZD-7624 is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0, displays 15-fold selectivity for p38α over p38β MAPK and >10,000-fold selectivity over p38γ and p38δ MAPK; inhibits LPS-induced TNF-α and IL-6 release in human alveolar macrophages pIC50 of 9.2 and 8.8, respectively; shows potential for prevention of exacerbations in COPD.COPD Phase 2 Discontinued.
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In VitroAZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50s of 8.4, 8.1, and 9.0.
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In Vivo——
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SynonymsAZD7624
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38 MAPK
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number1095004-78-6
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Formula Weight491.56
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Molecular FormulaC27H30FN5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (127.15 mM)
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SMILESO=C(NC1CC1)C2=CC(N3C(C(NC4(C5=CC=CC=C5OCCNC)CC4)=NC=C3)=O)=C(C)C(F)=C2
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Chemical NameN-cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Patel NR, et al. Int J Chron Obstruct Pulmon Dis. 2018 Mar 27;13:1009-1019.
2. Pehrson R, et al. Pharmacol Exp Ther. 2018 Mar 16. pii: jpet.117.246132.
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