Cart
sales@molnova.com
RETRA
CAS No. 1036069-26-7
RETRA( —— )
Catalog No. M10180 CAS No. 1036069-26-7
RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameRETRA
-
NoteResearch use only, not for human use.
-
Brief DescriptionRETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
-
DescriptionRETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetMDM2-p53
-
RecptorMDM2-p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1036069-26-7
-
Formula Weight269.333
-
Molecular FormulaC11H11NO3S2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1CSC(=N1)SCC(=O)C2=CC(=C(C=C2)O)O.Cl
-
Chemical Name2-((4,5-dihydrothiazol-2-yl)thio)-1-(3,4-dihydroxyphenyl)ethan-1-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.
2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51.
3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85.
molnova catalog
related products
-
NSC-66811
A potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.
-
MX69
A novel specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM.
-
MB725
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).
