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D-alpha-Hydroxyglutaric acid disodium salt
D-alpha-Hydroxyglutaric acid disodium salt
CAS No. 103404-90-6
D-alpha-Hydroxyglutaric acid disodium salt( D-2-HG | D-2-hydroxyglutarate )
Catalog No. M10168 CAS No. 103404-90-6
A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 42 | In Stock |
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| 25MG | 60 | In Stock |
|
| 50MG | 101 | In Stock |
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| 100MG | 177 | In Stock |
|
| 200MG | 264 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
| 5MG | 29 | In Stock |
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| 10MG | 45 | In Stock |
|
| 25MG | 64 | In Stock |
|
| 50MG | 104 | In Stock |
|
| 100MG | 183 | In Stock |
|
| 200MG | 272 | In Stock |
|
| 500MG | 456 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameD-alpha-Hydroxyglutaric acid disodium salt
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NoteResearch use only, not for human use.
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Brief DescriptionA competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
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DescriptionA competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
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In Vitro——
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In Vivo——
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SynonymsD-2-HG | D-2-hydroxyglutarate
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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Recptorα-KG
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number103404-90-6
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Formula Weight192.08
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Molecular FormulaC5H6Na2O5
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 32 mg/mL
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SMILES[O-]C(CC[C@H](C([O-])=O)O)=O.[Na+].[Na+]
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Chemical NamePentanedioic acid, 2-hydroxy-, disodium salt, (2R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
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