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D-alpha-Hydroxyglutaric acid disodium salt

CAS No. 103404-90-6

D-alpha-Hydroxyglutaric acid disodium salt( D-2-HG | D-2-hydroxyglutarate )

Catalog No. M10168 CAS No. 103404-90-6

A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 42 In Stock
25MG 60 In Stock
50MG 101 In Stock
100MG 177 In Stock
200MG 264 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
5MG 29 In Stock
10MG 45 In Stock
25MG 64 In Stock
50MG 104 In Stock
100MG 183 In Stock
200MG 272 In Stock
500MG 456 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    D-alpha-Hydroxyglutaric acid disodium salt
  • Note
    Research use only, not for human use.
  • Brief Description
    A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
  • Description
    A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    D-2-HG | D-2-hydroxyglutarate
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    α-KG
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    103404-90-6
  • Formula Weight
    192.08
  • Molecular Formula
    C5H6Na2O5
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 32 mg/mL
  • SMILES
    [O-]C(CC[C@H](C([O-])=O)O)=O.[Na+].[Na+]
  • Chemical Name
    Pentanedioic acid, 2-hydroxy-, disodium salt, (2R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30. 2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
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