Cart
sales@molnova.com
PF-04191834
CAS No. 1029317-21-2
PF-04191834( PF-4191834 )
Catalog No. M10139 CAS No. 1029317-21-2
PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
|
| 5MG | 46 | In Stock |
|
| 10MG | 72 | In Stock |
|
| 25MG | 149 | In Stock |
|
| 50MG | 254 | In Stock |
|
| 100MG | 367 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 798 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePF-04191834
-
NoteResearch use only, not for human use.
-
Brief DescriptionPF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.
-
DescriptionPF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM; displays 300‐fold over 12‐LO and 15‐LO, and no inhibition of the cyclooxygenase enzymes; is under clinical investigation for the oral treatment of asthma and pain.Pain Phase 2 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsPF-4191834
-
PathwayImmunology/Inflammation
-
TargetLipoxygenase
-
RecptorLipoxygenase
-
Research AreaNeurological Disease
-
IndicationPain
Chemical Information
-
CAS Number1029317-21-2
-
Formula Weight393.502
-
Molecular FormulaC22H23N3O2S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (254.13 mM)
-
SMILESO=C(C1(C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)CCOCC1)N
-
Chemical Name4-(3-((4-(1-methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)tetrahydro-2H-pyran-4-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Masferrer JL, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301.
2. Rzodkiewicz P, et al. Reumatologia. 2016;54(4):161-164. Epub 2016 Oct 5.
molnova catalog
related products
-
ZD-2138
ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolated airways in guinea pigs.
-
CJ-13,610 hydrochlor...
CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological effects of LTs.
-
EUK 134
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
