EUK 134( EUK-134 | EUK-134 | EUK-134 )

Catalog No. M19135 CAS No. 81065-76-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

EUK 134
Note

Research use only, not for human use.
Brief Description

EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
Description

EUK-134 is an antioxidant compound with superoxide dismutase and catalase activity for oxidative species such as peroxynitrite, superoxide, and hydrogen peroxide.
In Vitro

Cell Viability Assay Cell Line:NRK-52E cells Concentration:0, 1, 3, 10, 30, 100, and 300 μM Incubation Time:24 hours Result:Co-incubation with Paraquat (1 mM) and increasing concentrations of EUK-134 (1-300 μM) resulted in a significant reduction in paraquat-induced cellular injury and death at 100 and 300 μM.
In Vivo

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Synonyms

EUK-134 | EUK-134 | EUK-134
Pathway

Immunology/Inflammation
Target

Lipoxygenase
Recptor

Aβ
Research Area

Others-Field
Indication

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CAS Number

81065-76-1
Formula Weight

416.74
Molecular Formula

C18H18ClMnN2O4
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 10 mg/mL (24.00 mM)
SMILES

COC1=C2O[Mn]34(Cl)OC5=C(OC)C=CC=C5C=[N]3CC[N]4=CC2=CC=C1
Chemical Name

chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]]]-manganese

1. Baker K, et al. J Pharmacol Exp Ther. 1998, 284(1), 215-221.

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