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Org-26576
CAS No. 1026791-61-6
Org-26576( Org26576 | Org 26576 )
Catalog No. M10131 CAS No. 1026791-61-6
A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 101 | In Stock |
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| 50MG | 142 | In Stock |
|
| 100MG | 251 | In Stock |
|
| 200MG | 370 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOrg-26576
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NoteResearch use only, not for human use.
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Brief DescriptionA potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.
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DescriptionA potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516; increases neuronal cell proliferation and survival in adult rodent hippocampus; produces nootropic effects in vivo.Depression Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsOrg26576 | Org 26576
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research AreaNeurological Disease
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IndicationDepression
Chemical Information
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CAS Number1026791-61-6
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Formula Weight204.22518
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Molecular FormulaC11H12N2O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1N(CCC2)[C@]2([H])COC3=NC=CC=C13
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Chemical Name5H,7H-Pyrido[3,2-f]pyrrolo[2,1-c][1,4]oxazepin-5-one, 8,9,9a,10-tetrahydro-, (9aS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jordan GR, et al. Neuropharmacology. 2005 Aug;49(2):254-64.
2. Su XW, et al. Psychopharmacology (Berl). 2009 Oct;206(2):215-22.
3. Hamlyn E, et al. Behav Pharmacol. 2009 Oct;20(7):662-7.
4. Bursi R, et al. Psychopharmacology (Berl). 2011 Dec;218(4):713-24.
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