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Home - Products - Membrane Transporter/Ion Channel - iGluR - Org-26576

Org-26576

CAS No. 1026791-61-6

Org-26576( Org26576 | Org 26576 )

Catalog No. M10131 CAS No. 1026791-61-6

A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 41 In Stock
5MG 37 In Stock
10MG 61 In Stock
25MG 101 In Stock
50MG 142 In Stock
100MG 251 In Stock
200MG 370 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Org-26576
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.
  • Description
    A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516; increases neuronal cell proliferation and survival in adult rodent hippocampus; produces nootropic effects in vivo.Depression Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Org26576 | Org 26576
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Depression

Chemical Information

  • CAS Number
    1026791-61-6
  • Formula Weight
    204.22518
  • Molecular Formula
    C11H12N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1N(CCC2)[C@]2([H])COC3=NC=CC=C13
  • Chemical Name
    5H,7H-Pyrido[3,2-f]pyrrolo[2,1-c][1,4]oxazepin-5-one, 8,9,9a,10-tetrahydro-, (9aS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jordan GR, et al. Neuropharmacology. 2005 Aug;49(2):254-64. 2. Su XW, et al. Psychopharmacology (Berl). 2009 Oct;206(2):215-22. 3. Hamlyn E, et al. Behav Pharmacol. 2009 Oct;20(7):662-7. 4. Bursi R, et al. Psychopharmacology (Berl). 2011 Dec;218(4):713-24.
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