Azvudine( RO 0622 )

Catalog No. M10071 CAS No. 1011529-10-4

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Azvudine
Note

Research use only, not for human use.
Brief Description

Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor.
Description

Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM; inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations (IC50=10-100 nM).
In Vitro

Azvudine (RO-0622) displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively.
In Vivo

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Synonyms

RO 0622
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

——
Indication

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CAS Number

1011529-10-4
Formula Weight

286.223
Molecular Formula

C9H11FN6O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (436.73 mM)
SMILES

O=C1N=C(N)C=CN1[C@H]2[C@@H](F)[C@@H]([C@](CO)(N=[N+]=[N-])O2)O
Chemical Name

4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

1. Klumpp K, et al. J Biol Chem. 2008 Jan 25;283(4):2167-75.

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