BMS-961955( BMS961955 )

Catalog No. M11828 CAS No. 1431328-92-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-961955
Note

Research use only, not for human use.
Brief Description

BMS-961955 is an potent, allosteric inhibitor of HCV NS5B polymerase with EC50 of 7.9/4.3 nM for GT 1b/1a replicon respectively.
Description

BMS-961955 is an potent, allosteric inhibitor of HCV NS5B polymerase with EC50 of 7.9/4.3 nM for GT 1b/1a replicon respectively; shows weak activity against PXR; displayes significantly enhanced metabolic stability in CLM and HLM.
In Vitro

——
In Vivo

——
Synonyms

BMS961955
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

Infection
Indication

——

CAS Number

1431328-92-5
Formula Weight

658.833
Molecular Formula

C37H43FN4O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1(CC1)S(=O)(=O)NC(=O)C2=CC3=C(C=C2)C(=C4N3CC5(CC5C6=C4C=CC(=C6)F)C(=O)N7C8CCC7CN(C8)C)C9CCCCC9
Chemical Name

(4bS,5aR)-12-Cyclohexyl-3-fluoro-4b,5,5a,6-tetrahydro-N-[(1-methylcyclopropyl)sulfonyl]-5a-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-9-carboxamide

1. Zheng BZ, et al. Bioorg Med Chem Lett. 2017 Jun 11. pii: S0960-894X(17)30626-1.

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