AEM2( SIRT2 inhibitor AEM2 )

Catalog No. M10039 CAS No. 1005095-04-4

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HPLC

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Product Name

AEM2
Note

Research use only, not for human use.
Brief Description

SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM.
Description

SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2; sensitizes non-small cell lung cancer cell lines toward the induction of apoptosis by the DNA-damaging agent etoposide; elevates levels of p53 acetylation and increases expression of CDKN1A, PUMA and NOXA.
In Vitro

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In Vivo

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Synonyms

SIRT2 inhibitor AEM2
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

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Indication

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CAS Number

1005095-04-4
Formula Weight

409.533
Molecular Formula

C27H27N3O
Purity

>98% (HPLC)
Solubility

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SMILES

C1CC2CC1C3C2C4=C(C=CC(=C4)C(=O)NCC5=CN=CC=C5)NC3C6=CC=CC=C6
Chemical Name

6-phenyl-N-(pyridin-3-ylmethyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide

1. Hoffmann G, et al. J Biol Chem. 2014 Feb 21;289(8):5208-16.

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