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AZD-4818
CAS No. 1003566-93-5
AZD-4818( AZD4818 )
Catalog No. M10031 CAS No. 1003566-93-5
AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 56 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 150 | In Stock |
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| 25MG | 301 | In Stock |
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| 50MG | 444 | In Stock |
|
| 100MG | 663 | In Stock |
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| 200MG | 895 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD-4818
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NoteResearch use only, not for human use.
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Brief DescriptionAZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.
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DescriptionAZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner; significantly reduces neutrophil influx and TNF-α levels on bronchoalveolar lavage (BAL) following intratracheal administration in vivo.COPD Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAZD4818
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number1003566-93-5
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Formula Weight567.46
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Molecular FormulaC27H32Cl2N2O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (88.11 mM)
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SMILESCC(C)(C(=O)O)Oc1cc(c(cc1Cl)C(=O)NC)OC[C@H](CN2CCC3(CC2)Cc4cc(ccc4O3)Cl)O
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Chemical Name2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[benzofuran-2(3H),4'-piperidin]-1'-yl)-2-hydroxypropoxy]-4-[(methylamino)carbonyl]phenoxy]-2-methylpropanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kerstjens HA, et al. Respir Med. 2010 Sep;104(9):1297-303.
2. Norman P. Expert Opin Ther Pat. 2009 Nov;19(11):1629-33.
3. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.
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