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C-021
CAS No. 864289-85-0
C-021( C021 )
Catalog No. M16265 CAS No. 864289-85-0
C-021 is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 92 | In Stock |
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| 2MG | 62 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 302 | In Stock |
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| 50MG | 458 | In Stock |
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| 100MG | 642 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameC-021
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NoteResearch use only, not for human use.
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Brief DescriptionC-021 is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.
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DescriptionC-021 is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.
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In Vitro——
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In VivoAnimal Model:Male C57Bl/6 mice (20-25 g) with acute liver failure.Dosage:1 mg/kg Administration:i.p.; daily; for 3 days Result:Significantly less microgliosis, and significantly reduced the pERK1/2 to tERK1/2 ratio.
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SynonymsC021
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number864289-85-0
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Formula Weight467.658
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Molecular FormulaC27H41N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (106.92 mM)
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SMILESCOC1=C(C=C2C(=C1)C(=NC(=N2)N3CCC(CC3)N4CCCCC4)NC5CCCCCC5)OC
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Chemical Name2-([1,4'-bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yokoyama K, et al. Bioorg Med Chem. 2009 Jan 1;17(1):64-73.
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