C-021( C021 )

Catalog No. M16265 CAS No. 864289-85-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

C-021
Note

Research use only, not for human use.
Brief Description

C-021 is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.
Description

C-021 is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.
In Vitro

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In Vivo

Animal Model:Male C57Bl/6 mice (20-25 g) with acute liver failure.Dosage:1 mg/kg Administration:i.p.; daily; for 3 days Result:Significantly less microgliosis, and significantly reduced the pERK1/2 to tERK1/2 ratio.
Synonyms

C021
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

——

CAS Number

864289-85-0
Formula Weight

467.658
Molecular Formula

C27H41N5O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (106.92 mM)
SMILES

COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCC(CC3)N4CCCCC4)NC5CCCCCC5)OC
Chemical Name

2-([1,4'-bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine

1. Yokoyama K, et al. Bioorg Med Chem. 2009 Jan 1;17(1):64-73.

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