Lys05

Research use only, not for human use.

Lys05 (Lys01 trihydrochloride, PS-1001)is the water-soluble salt of Lys01, is a 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ); shows IC50 values of 3.6, 3.8, 6 and 7.9 uM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.

Lys05 (Lys01 trihydrochloride, PS-1001)is the water-soluble salt of Lys01, is a 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ); shows IC50 values of 3.6, 3.8, 6 and 7.9 uM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay;more potently accumulates within and deacidifies the lysosome, resulting in impaired autophagy and tumor growth; enhances sunitinib-mediated suppression of clear cell ovarian carcinoma (CCOC) cell viability.

Lys-05;Lys 05;Lys01 trihydrochloride;PS-1001

Autophagy

Autophagy

lysosomalautophagy(1205Lu);lysosomalautophagy(c8161);lysosomalautophagy(HT-29);lysosomalautophagy(LN229)

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1391426-24-6

549.75

C23H26Cl5N5

>98% (HPLC)

DMSO: 6.4 mg/mL, Need Ultrasonic; Water: 3 mg/mL (5.5 mM); Ethanol: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

CN(CCNC1=CC=NC2=CC(Cl)=CC=C12)CCNC3=CC=NC4=CC(Cl)=CC=C34.[H]Cl.[H]Cl.[H]Cl

N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine trihydrochloride

(-20℃)

With Ice Pack

≥ 2 years