Lurbinectedin
CAS No. 497871-47-3
Lurbinectedin ( PM01183 )
Catalog No. M26745 CAS No. 497871-47-3
Lurbinectedin is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 1791 | Get Quote |
|
5MG | 2664 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameLurbinectedin
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NoteResearch use only, not for human use.
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Brief DescriptionLurbinectedin is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.
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DescriptionLurbinectedin is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.(In Vitro):Lurbinectedin inhibits RMG1 and RMG2 cell growth (IC50: 1.25 and 1.16 nM, respectively). Lurbinectedin exhibits significant antitumor activity toward chemosensitive and chemoresistant human ovarian clear cell carcinoma (CCC) cells in vitro. Lurbinectedin-DNA adducts in living cells give rise to double-strand breaks, triggering S-phase accumulation, and apoptosis. Lurbinectedin is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumors. The potent cytotoxic activity of Lurbinectedin is ascertained in a 23-cell line panel with a mean GI50 value of 2.7 nM. (In Vivo):Lurbinectedin inhibits tumor growth significantly with no weight loss of treated animals, in four murine xenograft models of human cancer. Mouse CCC cell xenografts show that lurbinectedin significantly inhibits tumor growth. Lurbinectedin plus SN-38 causes a significant synergistic effect.
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SynonymsPM01183
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PathwayOthers
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TargetOther Targets
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Recptorkynurenine aminotransferase (KAT) II
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Research Area——
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Indication——
Chemical Information
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CAS Number497871-47-3
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Formula Weight784.9
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Molecular FormulaC41H44N4O10S
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Purity>98% (HPLC)
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Solubility——
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SMILES[H][C@@]12Cc3cc(C)c(OC)c(O)c3[C@@]([H])(N1C)[C@@]1([H])N([C@H]2O)[C@@]2([H])COC(=O)[C@]3(CS[C@]1([H])c1c(OC(C)=O)c(C)c4OCOc4c21)NCCc1c3[nH]c2ccc(OC)cc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nematollahi A, et al. Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders. Molecules. 2016 Jun 29;21(7).
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