Lurbinectedin

CAS No. 497871-47-3

Lurbinectedin( PM01183 )

Catalog No. M26745 CAS No. 497871-47-3

Lurbinectedin is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lurbinectedin
  • Note
    Research use only, not for human use.
  • Brief Description
    Lurbinectedin is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.
  • Description
    Lurbinectedin is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.(In Vitro):Lurbinectedin inhibits RMG1 and RMG2 cell growth (IC50: 1.25 and 1.16 nM, respectively). Lurbinectedin exhibits significant antitumor activity toward chemosensitive and chemoresistant human ovarian clear cell carcinoma (CCC) cells in vitro. Lurbinectedin-DNA adducts in living cells give rise to double-strand breaks, triggering S-phase accumulation, and apoptosis. Lurbinectedin is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumors. The potent cytotoxic activity of Lurbinectedin is ascertained in a 23-cell line panel with a mean GI50 value of 2.7 nM. (In Vivo):Lurbinectedin inhibits tumor growth significantly with no weight loss of treated animals, in four murine xenograft models of human cancer. Mouse CCC cell xenografts show that lurbinectedin significantly inhibits tumor growth. Lurbinectedin plus SN-38 causes a significant synergistic effect.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PM01183
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    kynurenine aminotransferase (KAT) II
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    497871-47-3
  • Formula Weight
    784.88
  • Molecular Formula
    C41H44N4O10S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (25.48 mM)
  • SMILES
    [H][C@@]12Cc3cc(C)c(OC)c(O)c3[C@@]([H])(N1C)[C@@]1([H])N([C@H]2O)[C@@]2([H])COC(=O)[C@]3(CS[C@]1([H])c1c(OC(C)=O)c(C)c4OCOc4c21)NCCc1c3[nH]c2ccc(OC)cc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nematollahi A, et al. Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders. Molecules. 2016 Jun 29;21(7).
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