Lucanthone

Research use only, not for human use.

Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

Lucanthone is orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity. Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, thereby inhibiting the synthesis of macromolecules. In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, resulting in unrepaired DNA strand breaks which may induce apoptosis. Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy through the disruption of lysosomal function. The multifunctional nuclease APE1 is a key component for DNA repair; its expression is often correlated with tumor cell resistance to radio- and chemotherapy. Check for active clinical trials or closed clinical trials using this agent. ( NCI Thesaurus )

Lucanthone monohydrochloride; Thiaxanthenone; miracil D

Endocrinology/Hormones

AChR

APE1

——

——

479-50-5

340.48

C20H24N2OS

98%

DMSO : 25 mg/mL 73.43 mM;

CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12

1-{[2-(diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one

(-20℃)

With Ice Pack

≥ 2 years