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Lofepramine

CAS No. 23047-25-8

Lofepramine( Lopramine | Amplit | Leo 640 | Gamanil )

Catalog No. M26742 CAS No. 23047-25-8

Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 37 Get Quote
5MG 59 Get Quote
10MG 82 Get Quote
25MG 169 Get Quote
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Biological Information

  • Product Name
    Lofepramine
  • Note
    Research use only, not for human use.
  • Brief Description
    Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine.
  • Description
    Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Lopramine | Amplit | Leo 640 | Gamanil
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    Topo II
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    23047-25-8
  • Formula Weight
    418.97
  • Molecular Formula
    C26H27ClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (119.34 mM)
  • SMILES
    CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.J P Braybrooke, et al. A phase II study of Razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis. Clin Cancer Res.2000; 6(12):4697-704.
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