Liraglutide( Liraglutide | NNC 90-1170 | NN2211 | Saxenda, Victoza )

Catalog No. M18218 CAS No. 204656-20-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Liraglutide
Note

Research use only, not for human use.
Brief Description

Liraglutide is a long-acting GLP-1 receptor agonist.
Description

Liraglutide is an analog of Glucagon-like Peptide 1 (GLP-1) and an agonist of the Glucagon-like Peptide 1 receptor that is used as a hypoglycemic agent and supplemental therapy in the treatment of Diabetes by patients who do not respond to Metformin.(In Vitro):Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide is an injectable drug for the treatment of type 2 diabetes, also can be used to treat obesity in adults with some related comorbidity. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells.
In Vitro

Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide is an injectable drugfor the treatment of type 2 diabetes, also can be used to treat obesity in adults with some related comorbidity. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells.
In Vivo

——
Synonyms

Liraglutide | NNC 90-1170 | NN2211 | Saxenda, Victoza
Pathway

Proteasome/Ubiquitin
Target

Cysteine Protease
Recptor

GLP-1
Research Area

Endocrinology
Indication

——

CAS Number

204656-20-2
Formula Weight

3751.25
Molecular Formula

C172H265N43O51
Purity

>98% (HPLC)
Solubility

H2O : 5 mg/mL 1.33 mM
SMILES

CCCCCCCCCCCCCCCC(=O)N[C@H](C(=O)O)CCC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)O)CCCNC(=N)N)CCCNC(=N)N)C(C)C)CC(C)C)Cc1c[nH]c2c1cccc2)C)[C@@H](CC)C)Cc1ccccc1)CCC(=O)O)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@@H](O)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc1[nH]cnc1)N)C)CCC(=O)O)Cc1ccccc1)CO)CC(=O)O)CO)CO)Cc1ccc(cc1)O)CC(C)C)CCC(=O)O)CCC(=O)N)C)C
Chemical Name

Glycine, L-histidyl-L-alanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-(N-(1-oxohexadecyl)-L-gamma-glutamyl)-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-

1. Bode B, et al. Am J Manag Care. 2011 Mar;17(2 Suppl):S59-70.

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