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Home - Products - Proteasome/Ubiquitin - Cysteine Protease - MK-0674

MK-0674

CAS No. 887781-62-6

MK-0674( —— )

Catalog No. M33431 CAS No. 887781-62-6

MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-0674
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.
  • Description
    MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
  • In Vitro
    MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Cysteine Protease
  • Recptor
    Cysteine Protease
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    887781-62-6
  • Formula Weight
    527.5
  • Molecular Formula
    C26H27F6N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C([C@@H](N[C@H]([C@](F)(F)F)C1=CC=C(C=C1)C2=CC=C([C@H](C(F)F)O)C=C2)CC(C)(C)F)=O)C3(C#N)CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.?
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