Leuprorelin

CAS No. 53714-56-0

Leuprorelin ( Leuprolide )

Catalog No. M19810 CAS No. 53714-56-0

Leuprolide is an agonist at pituitary GnRH receptors.GnRH receptor Leuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 177 In Stock
10MG 281 In Stock
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Biological Information

  • Product Name
    Leuprorelin
  • Note
    Research use only not for human use.
  • Brief Description
    Leuprolide is an agonist at pituitary GnRH receptors.GnRH receptor Leuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty.
  • Description
    Leuprolide is an agonist at pituitary GnRH receptors.GnRH receptor Leuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary inducing a transient early rise in gonadotrophin release. With continued use Leuprorelin causes pituitary desensitisation and/or down-regulation leading to suppressed circulating levels of gonadotrophins and sex hormones.By interrupting the normal pulsatile stimulation of and thus desensitizing the GnRH receptors it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.
  • Synonyms
    Leuprolide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GNRHR
  • Research Area
    Endocrinology
  • Indication
    Precocious puberty

Chemical Information

  • CAS Number
    53714-56-0
  • Formula Weight
    1209.4
  • Molecular Formula
    C59H84N16O12
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM;Water:1mg/mL
  • SMILES
    CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1
  • Chemical Name
    (S)-N-ethyl-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl)pyrrolidine-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Plosker GL Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer endometriosis and other sex hormone-related disorders. Drugs.1994 Dec;48(6):930-967.
molnova catalog
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