Lenacapavir( GS-6207 )

Catalog No. M26233 CAS No. 2189684-44-2

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Product Name

Lenacapavir
Note

Research use only, not for human use.
Brief Description

Lenacapavir is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells.
Description

Lenacapavir is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells.(In Vitro):Lenacapavir displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells. Lenacapavir shows sub-nanomolar potency in target cells with EC50 of 23 pM, in a full-cycle assay with EC50 of 25 pM and in producer cells with EC50 of 439 pM.
In Vitro

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In Vivo

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Synonyms

GS-6207
Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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CAS Number

2189684-44-2
Formula Weight

968.28
Molecular Formula

C39H32ClF10N7O5S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 200 mg/mL (206.55 mM)
SMILES

[H][C@]12C[C@@]1([H])C(F)(F)c1c2c(nn1CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)c1nc(ccc1-c1ccc(Cl)c2c(NS(C)(=O)=O)nn(CC(F)(F)F)c12)C#CC(C)(C)S(C)(=O)=O)C(F)(F)F
Chemical Name

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1.Tagliabue A, Rappuoli R. Vaccine adjuvants:the dream becomes real. Hum Vaccin. 2008 Sep-Oct;4(5):347-9.

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