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Latanoprost acid

CAS No. 41639-83-2

Latanoprost acid( —— )

Catalog No. M33406 CAS No. 41639-83-2

Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Latanoprost acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway.
  • Description
    Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
  • In Vitro
    Latanoprost acid (10-20 μM;24 hours) reduces he protein expressions of c-fos and NFATc1. Latanoprost acid (10μM with 50ng/ml RANKL) significantly inhibits ERK, p38, AKT and JNK. Latanoprost acid (10 μM, 20 μM) significantly inhibits the mature osteoclast formation. Western Blot Analysis Cell Line:Bone marrow-derived macrophages cells (BMMs) Concentration:10 μM, 20 μM Incubation Time:24 hours Result:Reduced he protein expressions of c-fos and NFATc1.
  • In Vivo
    Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) notably prevents LPS-induced bone destruction at a dose of 20mg/kg. Animal Model:8-week-old C57BL/6J mice Dosage:20 mg/kg Administration: Intraperitoneally injected; once a day for 7 days Result:Notably prevented LPS-induced bone destruction at a dose of 20mg/kg.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    41639-83-2
  • Formula Weight
    390.51
  • Molecular Formula
    C23H34O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (256.08 mM; Ultrasonic )
  • SMILES
    O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O)CCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Weinreb RN, et al. Effects of prostaglandins on the aqueous humor outflow pathways. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S53-64.?
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