Lamotrigine

CAS No. 84057-84-1

Lamotrigine( BW 430C | Epilepax | Lamictal | LTG )

Catalog No. M16122 CAS No. 84057-84-1

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
200MG 28 In Stock
500MG 41 In Stock
1G 65 In Stock

Biological Information

  • Product Name
    Lamotrigine
  • Note
    Research use only, not for human use.
  • Brief Description
    Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder.
  • Description
    Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. (In Vitro):Lamotrigine inhibits Veratrine evoked release of glutamate and aspartate with ED50 values of 21 μM for both amino acids, but Lamotrigine is less potent in the inhibition of GABA release (ED50=44 μM. At concentrations up to 300 μM, LTG has no effect on patassium-evoked amino acid.Lamotrigine is some five times less potent in the inhibition of Veratrine-evoked [3H]acetylcholine release (ED50=100 μM) than in glutamate or aspartate release.(In Vivo):Lamotrigine (IP, 30 min before pentylenetetrazol; 10 mg/kg, 15 mg/kg or 20 mg/kg) decreases the seizure intensity at the higher doses, it increases the latency to the first pentylenetetrazol-induced seizure in all studied doses compared with the controls.
  • In Vitro
    ——
  • In Vivo
    Animal Model:White male mice weighing 25-30 g Dosage:10 mg/kg, 15 mg/kg or 20 mg/kg Administration:Intraperitoneally 30 min before pentylenetetrazol Result:Had an anti-convulsive effect in seizure models, suppressing seizure intensity and influencing the latency to the first seizure.
  • Synonyms
    BW 430C | Epilepax | Lamictal | LTG
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT (human platelets)| 5-HT (rat brain synaptosomes)
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    84057-84-1
  • Formula Weight
    256.09
  • Molecular Formula
    C9H7Cl2N5
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 3 mg/mL (11.71 mM); DMSO: 10 mg/mL (39.04 mM)
  • SMILES
    NC1=NC(N)=C(C2=CC=CC(Cl)=C2Cl)N=N1
  • Chemical Name
    6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lipkind GM, et al. Mol Pharmacol. 2005 Dec;68(6):1611-22.
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