
Lamotrigine
CAS No. 84057-84-1
Lamotrigine( BW 430C | Epilepax | Lamictal | LTG )
Catalog No. M16122 CAS No. 84057-84-1
Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
200MG | 28 | In Stock |
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500MG | 41 | In Stock |
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1G | 65 | In Stock |
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Biological Information
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Product NameLamotrigine
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NoteResearch use only, not for human use.
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Brief DescriptionLamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder.
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DescriptionLamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. (In Vitro):Lamotrigine inhibits Veratrine evoked release of glutamate and aspartate with ED50 values of 21 μM for both amino acids, but Lamotrigine is less potent in the inhibition of GABA release (ED50=44 μM. At concentrations up to 300 μM, LTG has no effect on patassium-evoked amino acid.Lamotrigine is some five times less potent in the inhibition of Veratrine-evoked [3H]acetylcholine release (ED50=100 μM) than in glutamate or aspartate release.(In Vivo):Lamotrigine (IP, 30 min before pentylenetetrazol; 10 mg/kg, 15 mg/kg or 20 mg/kg) decreases the seizure intensity at the higher doses, it increases the latency to the first pentylenetetrazol-induced seizure in all studied doses compared with the controls.
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In Vitro——
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In VivoAnimal Model:White male mice weighing 25-30 g Dosage:10 mg/kg, 15 mg/kg or 20 mg/kg Administration:Intraperitoneally 30 min before pentylenetetrazol Result:Had an anti-convulsive effect in seizure models, suppressing seizure intensity and influencing the latency to the first seizure.
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SynonymsBW 430C | Epilepax | Lamictal | LTG
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT (human platelets)| 5-HT (rat brain synaptosomes)
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number84057-84-1
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Formula Weight256.09
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Molecular FormulaC9H7Cl2N5
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Purity>98% (HPLC)
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SolubilityEthanol: 3 mg/mL (11.71 mM); DMSO: 10 mg/mL (39.04 mM)
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SMILESNC1=NC(N)=C(C2=CC=CC(Cl)=C2Cl)N=N1
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Chemical Name6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lipkind GM, et al. Mol Pharmacol. 2005 Dec;68(6):1611-22.
molnova catalog



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