LYS228( LYS-228 | LYS 228 )

Catalog No. M12777 CAS No. 1810051-96-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

LYS228
Note

Research use only, not for human use.
Brief Description

LYS228 is a novel potent monobactam that shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae with MIC90 of 2 ug/ml.
Description

LYS228 is a novel potent monobactam that shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae with MIC90 of 2 ug/ml; LYS228 is stable against Metallo-β-lactamases (MBLs), and shows small or no MIC shifts for most SBLs (serine β-lactamases), including CTX-Ms, KPCs and OXA-types.Bacterial Infection Phase 2 Clinical.
In Vitro

——
In Vivo

——
Synonyms

LYS-228 | LYS 228
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

Bacterial Infection

CAS Number

1810051-96-7
Formula Weight

518.472
Molecular Formula

C16H18N6O10S2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CC1(C(=O)O)ON=C(C2=CSC(=N2)N)C(=O)NC3C(N(C3=O)S(=O)(=O)O)CN4CCOC4=O
Chemical Name

1-((((Z)-1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3-yl)amino)ethylidene)amino)oxy)cyclopropane-1-carboxylic acid

1. Reck F, et al. Bioorg Med Chem Lett. 2018 Feb 15;28(4):748-755.

Calculator

molnova catalog