FR194738

Research use only, not for human use.

FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.

FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.(In Vitro):FR194738 inhibits cholesterol biosynthesis in HepG2 cells (IC50 = 2.1 nM). FR194738 concentration-dependently inhibits hamster liver microsomal squalene epoxidase activity (IC50 = 14 nM). FR194738 inhibits the incorporation of [14C]acetate in intact HepG2 cells into free cholesterol (IC50 = 4.9 nM) and cholesteryl ester (IC50 = 8.0 nM) in a concentration-dependent manner. FR194738 induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene.(In Vivo):FR194738 (32 and 100 mg/kg) reduces the serum levels of total, non HDL and HDL cholesterol, and triglyceride and increases HMG-CoA reductase activity by 1.3-fold at a dose of 32 mg/kg.

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GPCR/G Protein

Antibacterial

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204067-52-7

476.1

C27H38ClNO2S

>98% (HPLC)

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Cl.CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCC(C)(C)OCc2ccsc2)c1

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(-20℃)

With Ice Pack

≥ 2 years