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LY3372689
CAS No. 2241514-56-5
LY3372689( —— )
Catalog No. M35580 CAS No. 2241514-56-5
LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 152 | Get Quote |
|
| 5MG | 235 | Get Quote |
|
| 10MG | 353 | Get Quote |
|
| 25MG | 615 | Get Quote |
|
| 50MG | 906 | Get Quote |
|
| 100MG | 1341 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLY3372689
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NoteResearch use only, not for human use.
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Brief DescriptionLY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
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DescriptionLY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. LY3372689 can be used for tauopathies research, including Alzheimer’s disease.
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In Vitro——
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In VivoLY3372689 shows a dose-dependent change in OGA enzyme occu-pancy (EO) following a single oral dose with a maximum EO of greater than 90% in rat.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMicrotubule Associated
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Research Area——
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Indication——
Chemical Information
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CAS Number2241514-56-5
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Formula Weight383.44
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Molecular FormulaC16H22FN5O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (651.99 mM; Ultrasonic )
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SMILESC[C@H]1C[C@H](CCN1Cc1sc(NC(C)=O)nc1F)OCc1noc(C)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sergey Shcherbinin, et al. Brain target occupancy of LY3372689, an inhibitor of the O-GlcNAcase (OGA) enzyme: Translation from rat to human. Alzheimer's & Dementia. 07 December 2020 .
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