GK921
CAS No. 1025015-40-0
GK921 ( GK921; GK-921; GK 921 )
Catalog No. M17119 CAS No. 1025015-40-0
GK921 is a transglutaminase 2 (TGase) inhibitor.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 76 | In Stock |
|
5MG | 113 | In Stock |
|
10MG | 186 | In Stock |
|
25MG | 298 | In Stock |
|
50MG | 478 | In Stock |
|
100MG | 653 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGK921
-
NoteResearch use only, not for human use.
-
Brief DescriptionGK921 is a transglutaminase 2 (TGase) inhibitor.
-
DescriptionGK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0.905 μM). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC.
-
SynonymsGK921; GK-921; GK 921
-
PathwayOthers
-
TargetOther Targets
-
RecptorTGase
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1025015-40-0
-
Formula Weight344.42
-
Molecular FormulaC21H20N4O
-
Purity98%
-
SolubilityDMSO : ≥ 30 mg/mL 87.11 mM
-
SMILESC1CCN(C1)CCOc1c(nc2c(n1)cccn2)C#Cc1ccccc1
-
Chemical Name3-(phenylethynyl)-2-(2-(pyrrolidin-1-yl)ethoxy)pyrido[2,3-b]pyrazine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ku BM,et al. Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models.J Cancer Res Clin Oncol. 2014 May;140(5):757-67.
molnova catalog
related products
-
Diisohexyl phthalate
Diisohexyl phthalate is a class of dialkyl phthalate esters and a plasticizer.
-
Bromodeoxyuridine (B...
Bromodeoxyuridine (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.
-
4-Hydroxy-3-nitrophe...
It is a small molecular drug, active to Ig heavy chain V-I region and Ig gamma-2 chain C region.